Placental ischemia-induced increases in brain water content and cerebrovascular permeability: role of TNF-α
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منابع مشابه
Placental ischemia-induced increases in brain water content and cerebrovascular permeability: role of TNF-α.
Cerebrovascular complications and increased risk of encephalopathies are characteristic of preeclampsia and contribute to 40% of preeclampsia/eclampsia-related deaths. Circulating tumor necrosis factor-α (TNF-α) is elevated in preeclamptic women, and infusion of TNF-α into pregnant rats mimics characteristics of preeclampsia. While this suggests that TNF-α has a mechanistic role to promote pree...
متن کاملPlacental Ischemia-induced Increases in Brain Water Content and Cerebrovascular Permeability:
Placental Ischemia-induced Increases in Brain Water Content and Cerebrovascular Permeability: 1 Role of TNFα 2 Junie P. Warrington, Heather A. Drummond, Joey P. Granger, Michael J. Ryan 3 4 Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS 5 39216 6 7 Running head: Placental Ischemia, TNFα and the Brain 8 9 Word Count: 5744 10 11 Corresponding Author: ...
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Magnesium sulfate (MgSO4) is the most widely used therapy in the clinic to prevent the progression of preeclampsia, a hypertensive disorder of pregnancy, to eclampsia. Eclampsia, manifested as unexplained seizures and/or coma during pregnancy or postpartum, accounts for ~13% of maternal deaths worldwide. While MgSO4 continues to be used in the clinic, the mechanisms by which it exerts its prote...
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Cerebrovascular events contribute to ~40% of preeclampsia/eclampsia-related deaths, and neurological symptoms are common among preeclamptic patients. We previously reported that placental ischemia, induced by reducing utero-placental perfusion pressure, leads to impaired myogenic reactivity and cerebral edema in the pregnant rat. Whether the impaired myogenic reactivity is associated with alter...
متن کاملBrain edema and cerebrovascular permeability during cerebral ischemia in rats.
Focal cerebral ischemia was produced by occluding the left middle cerebral artery in 769 rats. Permeability of the blood-brain barrier to small or large molecules was evaluated qualitatively using Evans blue or sodium fluorescein and quantitatively using the transfer indexes of iodine-125-labeled bovine serum albumin or [14C]sucrose. Water content was determined using wet and dry weights and so...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2015
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00372.2015